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William Gunn

Graduate Research at Tulane University

New Orleans, LA United States

What I Do:

I am a senior graduate student at the Tulane Center for Gene Therapy. My dissertation is entitled ?Investigating the Role of Human Multipotent Mesenchymal Stromal Cells in the Repair of Bone", in which I developed a model of multiple myeloma in immunodeficient mice and used it to test small molecule inhibitors of the interaction between multiple myeloma and bone precursor cells.

My profile is here and my CV is here.

I have also consulted with an as-yet nonpublic startup on the manufacture of nanoscale molecular diagnostics instrumentation.

Expertise:

Experience:

Tulane University

Graduate Research

Apr 2002 - Current

My work at Tulane involves self-guided experimental research on the relationship between Human Adult Stem Cells and cancer. I work with a team of 30 people, and my responsibilities also include managing and directing the research of incoming graduate students and summer interns.

Education:

Tulane University

PhD TBA 2008, Adult Stem Cells, Molecular Biology, Cancer

2002 - 2008

Member of International Society for Cellular Therapy
Louisiana Board of Regents Fellow
Science Blogger

The University of Southern Mississippi

B.S. , Molecular Biology

1996 - 2001

Undergraduate research activities included research on bacterial pathogenesis, eukaryotic transcriptional regulation, and the molecular biology of learning and memory.

Publications:

The promise of canonical Wnt signaling modulators in enhancing bone repair.

Drug news & perspectives 19, 445-452

A review article discussing the use of Wnt-modulating drugs in diseases of bone.

2006

The promise of canonical Wnt signaling modulators in enhancing bone repair.

Drug news & perspectives 19, 445-452

A review article discussing the use of Wnt-modulating drugs in diseases of bone.

2006

Dkk-1-derived Synthetic Peptides and Lithium Chloride for the Control and Recovery of Adult Stem Cells from Bone Marrow.

ournal of Biological Chemistry 280, 2309-2323

A research article presenting Dkk1 and Wnt-mimetics as agents for in vitro manipulation of hMSCs.

2005

How Wnt Signaling Affects Bone Repair by Mesenchymal Stem Cells from the Bone Marrow.

Annals of the New York Academy of Sciences 1049, 97-106

A review article discussing the role of hMSCs in disease of bone.

2005

Dkk-1-derived Synthetic Peptides and Lithium Chloride for the Control and Recovery of Adult Stem Cells from Bone Marrow.

ournal of Biological Chemistry 280, 2309-2323

A research article presenting Dkk1 and Wnt-mimetics as agents for in vitro manipulation of hMSCs.

2005

An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction.

Anal Biochem 329, 77-84

A methods paper describing a novel assay for calcium in biomineralized cultures.

2004

An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction.

Anal Biochem 329, 77-84

A methods paper describing a novel assay for calcium in biomineralized cultures.

2004

An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction.

Anal Biochem 329, 77-84

A methods paper describing a novel assay for calcium in biomineralized cultures.

2004

A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma. Open in a new window

How Wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow. Open in a new window

Awards and Honors:

Louisiana Board of Regents Fellow

2002

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